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KMID : 0379119830110040193
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Korean Journal of Mycology
1983 Volume.11 No. 4 p.193 ~ p.193
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Studies on Bacterial Resistance to Antibiotics (3)
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Abstract
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To clarify resistance mechanisms of lincosamide antibiotics, it was examined whether lincosamide antibiotics was able to induce high resistance to macrolide and lincosmade antibiotics against EMR-1 strain of Bacillus species. And it was also examined whether the inducible resistance was plasmid-mediated or chromosome-mediated. This strain was identified as Bacillus licheniformis by its morphological and physiological characteristics. The subinhibitory concentrations of lincomycin and clindamycin induced high resistance in the strain to lincosamide antibiotics, but not to macrolide antibiotics. The inducible resistance was eliminated by treating the strain with ethidium bromide. These results indicate, therefore, that the inducible resistance of B. licheniformis to macrolide and lincosamide antiobiotics is plasmid mediated, but not chromosome-mediated.
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